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- Classical pathway: Is considered part of the adaptive immune response since it begins with the formation of Ag: Ab complexes. These complexes are soluble found in antibodies that bind to an epitope, situated for bacterial or viral cell membranes. Soluble Ag:Ab complexes are referred to as immune complexes and only these complexes are formed by IgM or certain subclasses of IgG-abs are capable of activating the classical complement pathway. Th initial stage of activation involves the components C1, C2, C3, and C4, which are present in the plasma as zymogens.
- Phosphatidyl serine: The phospholipid restricted to the cytoplasmic side of the membrane, and the change in its location serves to signal the immune system that the cell is undergoing apoptosis.
- Alternative tickover pathway: The pathway initiated when C3 at high concentration in serum undergoes spontaneous hydrolysis as its internal thioester bond, yielding the molecule C3(H20).
Reference
- OrlandoinMiami. "Learn New Words." Orlando Espinosa. N.p., 30 Oct. 2015. Web. 08 Dec. 2016.
