Blog #2 Investigation

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When I was searching up more information about the bone marrow, a condition came up during one of my researches called Amyloidosis. Amyloidosis is a condition where abnormal proteins called amyloid builds up in the tissue or organs. These proteins are produced in the bone marrow. Due to this build up, that affects their shape and function. My sources explains the types of amyloidosis, which are: Primary (AL) amyloidosis--seen in people with blood cancer and affects the kidneys, liver, heart, and certain nerves. Secondary (AA) amyloidosis--results from another chronic diseases such as lupus, rheumatoid arthritis, Crohn's disease. Familial Amyloidosis--this is passed down from families. It is caused by abnormal amyloid transthyretin (TTR) protein made in the liver. Dialysis-related amyloidosis--mostly occurs in the elderly that have been in dialysis for more than 5 years.
Although, some types of amyloid proteins have been linked to Alzheimer's disease but the brain is rarely involved in systemic amyloidosis. I have a lot of questions involving this disorder. Since it's produced in the bone marrow, why isn't it autoimmune? People with this condition, do they make enough CD4 cells & B cells? What is/are the main purpose(s) of amyloid proteins? What are they intended for? So many questions! I'm still researching on this topic...Amyloidosis Pt. 2 coming soon! :)

Works Cited

• "Amyloidosis: Symptoms, Treatments, Prognosis, Causes." WebMD. WebMD, 16 Apr. 2005. Web. 09 Sept. 2016.
• Tanzi, R. E., A. Mcclatchey I., E. Lamperti D., L. Villa-Komaroff, J. Gusella F., and R. Neve L. "Protease Inhibitor Domain Encoded by an Amyloid Protein Precursor MRNA Associated with Alzheimerʼs Disease." Alzheimer Disease & Associated Disorders 2.4 (1988): 383. Web.