DICTIONARY
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- Recombination Signal Sequences (RSS): These are highly conserved heptamer and nonamer nucleotide sequences that serve as signals for the gene rearrangement process and flank each germline V, D, and J segment.
- Terminal Deoxynucleotidyl Transferase (TdT): One of the three proteins implicated in V(D)J recombination that is responsible for the generation of additional diversity in the CDR3 region of the antibody heavy chain. TdT is also expressed in developing lymphocytes and adds untemplated "N" nucleotides to the free 3' termini of coding ends following their cleavage by recombination activation gene (RAG) 1 & 2 recombinases.
- Coding joints: The nucleotide sequence at the point of union of coding sequences during V(D)J rearrangement to form rearranged antibody or T-cell receptor (TCR) genes.
- Signal joints: The joints between the heptamers from the RSSs.
- Palindromic Nucleotides: Nucleotide that forms at the V-D and D-J junction by asymmetric clipping of the hairpin junction formed by RAG1/2-mediated DNA cleavage.
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Work-cited
- By a Process Called Chemotaxis, They Reach Extravascular Tissue within 48 Hours Inflammatory Process. They Recognize and Eat up Just like Neutrophils. "Immense Immunology Insight." Immense Immunology Insight. N.p., n.d. Web. 28 Oct. 2016. <http://immense-immunology-insight.tumblr.com/page/10>.
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